Week 7 kicks off with Pittsburgh at Cincinnati on Thursday Night Football, followed by London’s Rams vs. Jaguars and the Colts at Chargers. Bills and Ravens are on bye. The odds table shows a mix of sizable favorites and close picks, including Steelers -5.5 at CIN, Rams -3.5 over JAX, and Chiefs as heavy favorites. Several matchups churn high-scoring potential while others hinge on defensive play and game script. Rosters should heed byes and travel effects as the slate unfolds.

Key Week 7 themes: spread-driven fantasy value in shootouts (TB vs DET, PHI vs MIN, ATL vs SF), streaming defenses in favorable matchups, and careful lineup construction around late-window games (IND-LAC, WSH-DAL). Monitor injury updates and weather, especially for London and prime time games, to capitalize on mismatches and avoid landmines.

Kimani Vidal surged to the top of Week 7 waiver priorities after stepping in for Omarion Hampton, posting a 70% snap share, 18 carries for 124 yards, and a receiving TD in Week 6. With Hampton out for multiple games, Vidal projects as a solid RB2/RB3 in many leagues as the Chargers lean on him in a reshaped backfield.

Meanwhile Tyjae Spears, Bam Knight, and Kendre Miller all delivered clear rostering upside with expanded roles in Week 6: Spears led Tennessee's backfield in touches, while Knight and Miller showed upside in Arizona and New Orleans’ offenses, respectively. Kyle Monangai and Kenneth Gainwell offered promising depth in Chicago and Pittsburgh, with Jaydon Blue and Sean Tucker presenting longer-term stash possibilities for depth charts shaken by injuries and byes. A broad set of handcuff and secondary options—Monangai, Monangai, Lloyd, Allgeier, Gordon II, Robinson, Corum and Davis—give fantasy managers a layered waiver plan for Week 7.

Week 7 bye weeks hit Buffalo and Baltimore, squeezing rosters further. The article emphasizes targeting breakout pass-catching and goal-line back options, balancing upside against opportunity, and using tools like Who Should I Pickup to compare several players. The overarching theme: injuries and workload shifts have created new value across multiple backfields, making a precise, matchup-aware waiver strategy essential for Week 7.